from Harnoss JC, Elrub QMA, Jung JO, Koburger T, Assadian O, Dissemond J, Baguhl R, Papke R, Kramer A 2019
published in Wound Rep Reg 27(2): 183-189
DOI 10.1111/wrr.12689

Irritative potency of selected wound antiseptics in the hen's egg test on chorioallantoic membrane to predict their compatibility to wounds.

PHMB-containing solutions and products are superior to other antiseptics regarding their local tolerability.

Though some antiseptic solutions in use might prevent infections, their tissue toxicity delays the healing process. The authors investigated the irritation potential of selected surgical irrigation solutions using a hen's egg test. No irritation potential was found for polyhexanide (PHMB)-containing solutions, while the highest irritation was observed for ocentidine and chlorhexidine (CHG) solutions. PHMB was regarded by the authors as superior to other antiseptics.

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