Are disposable gloves required during handling of patients infected with multi-drug resistant Gram-negative pathogens, even if contact with secretions, blood or other fluids is excluded?

It depends on the resistance level of the pathogen. It is recommended to wear disposable gloves when handling patients infected with multi-drug resistant Gram-negative pathogens.

Background:
In case of isolation due to the resistance level of the pathogen, the Robert Koch Institute recommends wearing gloves in case of probable (basic hygiene) and possible contact with blood, secretions, excretions, or contaminated surfaces. A possible contact cannot be excluded in the nursing sector.

References:
Hygiene measures in case of infections or colonisation with multiresistant gram-negative strains. KRINKO (2012) Hygienemaßnahmen bei
Infektionen oder Besiedlung mit multiresistenten gramnegativen Stäbchen. Bundesgesundheitsbl. 55: 1311-1354.