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Vancomycin-resistant Staphylococcus aureus. Multi-resistant Staphylococcus aureus isolates or strains that not only are resistant to all available beta-lactam antibiotics (e.g. penicillin), but also to vancomycin. In 2002, two vancomycin-resistant MRSA strains were isolated in the U.S. and termed VRSA. When spreading widely, VRSA may significantly limit therapeutic options.