Pathogens

Clostridioides difficile
(spore-forming bacterium)

Bacterial spores
Almost eternal: some bacterial spores are able to survive for several hundred years.

Clostridioides difficile (formaly Clostridium difficile) is an anaerobic, spore-forming, Gram-positive, rod-shaped bacterium belonging to the Clostridiaceae family.

The pathogen is often responsible for diarrhoea following a course of antibiotic therapy (antibiotic-associated diarrhoea).

A new Clostridioides difficile strain, the ribotype 027, is particularly virulent due to very high levels of toxin A and B production. The cause of the increasing virulence is supposed to be a genetic modification: the virulent C. difficile isolate misses a gene that usually delimits toxin release.

The main transmission path is direct or indirect contact with contaminated persons or objects.

» Necessary spectrum of antimicrobial activity
Sporicidal



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Knowledge Database

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