from Chindera et al. 2016
published in Sci Rep 6: 23121
DOI 10.1038/srep23121

The antimicrobial polymer PHMB enters cells and selectively condenses bacterial chromosomes

Surgical wound irrigation with antimicrobial active ingredients can help to prevent surgical site infections

The study investigated the mode of action of polihexamethylene biguanide (PHMB). The authors show a differential mode of action on bacterial cells and host cells, leading to a selective inactivation of bacterial cells and making resistances unlikely.