A multimodal strategy for cleaning and disinfecting frequently touched surfaces in hospitals can improve cleaning performance and reduce the incidence of clinically relevant pathogens, as shown here for vancomycin-resistant enterococci (VRE). After the intervention, infections with VRE were significantly reduced from 0.35 to 0.22 per 10,000 occupied bed days. In addition, an increase in frequent touch points being cleaned was observed.