Study

Reduction of Postoperative Wound Infections by Antiseptica (RECIPE)?: A Randomized Controlled Trial.

Study
Reduction of Postoperative Wound Infections by Antiseptica (RECIPE)?: A Randomized Controlled Trial.
from
Strobel RM, Leonhardt M, Krochmann A, Neumann K, Speichinger F, Hartmann L, Lee LD, Beyer K, Daum S, Kreis ME, Lauscher JC
Publication Year
2020
Published in
Ann Surg 272(1): 55-64
DOI
10.1097/SLA.0000000000003645
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Surgical wound irrigation with PHMB reduced the rate of surgical site infections by 38% compared to irrigation with saline.

In a clinical study patients were either treated with saline or polyhexanide (PHMB) for intraoperative wound irrigation. Significantly less surgical site infections (SSI) were observed for patients treated with PHMB compared to saline (38% less SSI). For saline, 67.7% of intraoperative swabs taken after irrigation were contamination positive, for PHMB only 21.6%.

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